About Me
Computational Biology and Bioinformatics Consulting Services
Mengshu Xu, PhD
Employment History
Principal Scientist, Bioinformatics Gilead Sciences | Foster City, CA | 2021 - 2025 •Led bioinformatics for 2 oncology projects from research through IND filing and clinical trials, respectively •Served as bioinformatics lead for 30+ immune oncology and 4 tumor intrinsic pipeline projects, demonstrating strong multitasking and collaboration skills •Uncovered key immunogenicity mechanisms through MHC-I peptide Mass spec sequencing analysis, revealing crucial insights into tumor cell neo-antigen presentation with findings slated for publication •Developed a standardized annotation framework for scRNA tumor immune datasets and supervised annotation efforts, creating high-value internal data resources now utilized daily across research teams •Integrated mouse syngeneic model scRNA data into a comprehensive reference tool, accelerating cross-study comparisons and rational model selection based on pathway activation signatures and markers •Published and presented research at SITC on CD47 expression patterns across cancer types, establishing important correlations with phagocytic macrophage content in the tumor microenvironment
Computational Scientist II, RAPT Therapeutics | South San Francisco, CA | 2018 -2021 •Led computational biology strategy for three preclinical immune-oncology projects and a key academic collaboration •Implemented data-driven in vivo model selection: leveraged RNA expression profiles from syngeneic tumor models to successfully predict responder models, which were confirmed through subsequent in vivo experiments •Established the 10X Chromium single-cell RNA sequencing platform for internal use at RAPT, incorporating advanced CITE-seq and sample hashing methodologies and trained bench scientists on protocol execution •Conducted collaborative research with Dr. James Talmadge's lab at U Nebraska, implementing scRNA sequencing by setting up the 10X platform on-site. Profiled cancer patient immune cells and characterized immune suppressive myeloid cell populations •Initiated and directed two strategic biomarker discovery project across RAPT disease areas (inflammation and IO), mentoring a Computational Biology Intern to successful project execution and career advancement
Education and Training
Postdoctoral Fellow, University of California, San Francisco | 2015 – 2018 Supervisor: Iwei Yeh Identified SPRED1 (RAS negative regulator) mutations in melanoma through genomic analysis of clinical samples, expanding the known melanoma pathogenic mutation landscape. (Co-first author, Science 2018)
PhD in Molecular Genetics, University of Toronto | 2007-2014 Supervisor: Marc Meneghini Thesis: Developmental Control Throughout the Budding Yeast Life Cycle by Jhd2, a JARID family Histone H3 Lysine-4 Demethylase. (First author, Developmental Cell 2012)
Honours Bachelor of Science, with High Distinction, University of Toronto | Toronto, ON | 2007-2014 Specialist in Molecular Genetics and Microbiology
Expert Business Consultant
Our Story
We are a team of experienced consultants dedicated to helping businesses thrive. Our tailored solutions and strategic advice pave the way for sustainable growth and long-term success.
Bioinformatics Infrastructure
Tailored analysis pipeline solutions for specific research needs
Target Discovery & Validation
Identification of novel drug targets and validation of targets by multi-omic resources
Molecular Project support
WGS/WES, RNA seq, scRNA seq, TCR seq, Protein peptidomics, Spatial seq etc.
Full life cycle support from experiment design to raw data processing, analysis and biological interpretation
AI/ML based projects
Efficiency Solutions
